• Sinh học - Chapter 11 (part 2): Regulation of glycolysisSinh học - Chapter 11 (part 2): Regulation of glycolysis

    Free Energy Change in Glycolysis Control Points in Glycolysis Effect of ATP on PFK-1 Activity

    ppt15 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1012 | Lượt tải: 0

  • Sinh học - Chapter 11 (Part 1) GlycolysisSinh học - Chapter 11 (Part 1) Glycolysis

    Substrate level phosphorylation generates second ATP Large, negative G - regulation! Allosterically activated by AMP, F-1,6-bisP Allosterically inhibited by ATP and acetyl-CoA

    ppt24 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1066 | Lượt tải: 0

  • Sinh học - Chapter 10: Introduction to metabolismSinh học - Chapter 10: Introduction to metabolism

    Enzyme Regulation of Flux Common mechanisms Feedforward activation

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  • Sinh học - Chapter 9 (part 1): Lipids and membranesSinh học - Chapter 9 (part 1): Lipids and membranes

    Common unsaturated fatty acids Unusual fatty acids can function analogously to unsaturated Enzymes used to Dissect Phospholipid Structure

    ppt12 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1076 | Lượt tải: 0

  • Sinh học - Chapter 8 (part2): Carbohydrates: Oligo - And polysaccharidesSinh học - Chapter 8 (part2): Carbohydrates: Oligo - And polysaccharides

    Structure of the ABO blood group carbohydrates, R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)

    ppt19 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1043 | Lượt tải: 0

  • Sinh học - Chapter 8 (part 1): CarbohydratesSinh học - Chapter 8 (part 1): Carbohydrates

    Glucose Fructose Ribulose Glyceraldehyde Dihydroxyacetone

    ppt19 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1062 | Lượt tải: 0

  • Sinh học - Chapter 7 (part 2): CofactorsSinh học - Chapter 7 (part 2): Cofactors

    Protein coenzyme Heme containing proteins Fe3+ can undergo reversible one electron reduction Impt in redox rxns Classified based on the basis of their visible absorbance spectra

    ppt16 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1071 | Lượt tải: 0

  • Sinh học - Chapter 7 (part 1): CofactorsSinh học - Chapter 7 (part 1): Cofactors

    Thiamin is the first Vitamin discovered (Vital amine = Vitamin) Deficiencies lead to disease called Beriberi (neurological disorders, heart problems, anorexia) Beriberi prevealent in undeveloped countries where polished grains make up the majority of the diet. Associated with alcohol related disorders (Wernickes-Korskofff syndrome – memory loss,...

    ppt22 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1034 | Lượt tải: 0

  • Sinh học - Chapter 6: Mechanisms of enzyme actionSinh học - Chapter 6: Mechanisms of enzyme action

    Trypsin, chymotrypsin, elastase, thrombin, subtilisin, plasmin, TPA All involve a serine in catalysis - thus the name Ser is part of a "catalytic triad" of Ser, His, Asp (show over head) Serine proteases are homologous, but locations of the three crucial residues differ somewhat Substrate specificity determined by binding pocket

    ppt35 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1060 | Lượt tải: 0

  • Sinh học - Chapter 5 (part 2): Enzyme kineticsSinh học - Chapter 5 (part 2): Enzyme kinetics

    Some enzyme catalyzed rxns show more complex behavior E + S<->ES<->EZ<->EP<-> E + P With M-M can look only at rate limiting step Often more than one substrate E+S1<->ES1+S2<->ES1S2<->EP1P2<-> EP2+P1<-> E+P2 Must optimize one substrate then calculate kinetic parameters for the other Assumes k-2 = 0 Assume steady state conditions

    ppt22 trang | Chia sẻ: nguyenlam99 | Ngày: 11/01/2019 | Lượt xem: 1051 | Lượt tải: 0