Sinh học - Chapter 8 (part2): Carbohydrates: Oligo - And polysaccharides

Chapter 8 (part2)Carbohydrates: oligo- and polysaccharidesGlycosidic LinkageDisaccharidesmaltosecellobioselactosesucrose(a-D-glucosyl-(1->4)-b-D-glucopyranose)(b-D-glucosyl-(1->4)-b-D-glucopyranose)(b-D-galactosyl-(1->4)-b-D-glucopyranose)(a-D-glucosyl-(1->2)-b-D-fructofuranose)Higher OligosaccharidesOligosaccharide groups are incorporated in to many drug structuresPolysaccharidesAmylose and AmylopectinIodine binding to starchglycogenDextransCelluloseCellulose vs AmyloseGlucose units rotated 180o relative to next residuecelluloseamyloseCelluloseChitinChitin vs CelluloseGlycoproteinsO-linked GlycoproteinsBlood ABO AntigensStructure of the ABO blood group carbohydrates,R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound formopen square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)N-linked Glycoproteins