Sinh học - Chapter 12 (part 1): Citric acid cycle

Chapter 12 (part 1)Citric Acid CycleGylcolysisTCA CycleElectron Transport andOxidative phosphorylationEntry into the TCA CyclePyruvate DehydrogenaseCitrate SynthaseOnly step in TCA cycle that involves the formation of a C-C bondAconitaseIsocitrate Dehydrogenase -Ketoglutarate DehydrogenaseSuccinyl-CoA SynthetaseFumaraseMalate DehydrogenaseReduced Coenzymes Fuel ATP ProductionAcetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20  HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+Isocitrate Dehydrogenase 1 NADH=2.5 ATP a-ketoglutarate dehydrogenase 1 NADH=2.5 ATPSuccinyl-CoA synthetase 1 GTP=1 ATPSunccinate dehydrogenase 1 QH2=1.5 ATPMalate Dehydrogenase 1 NADH=2.5 ATPTotal of 10 ATPs gained from oxidation of 1 Acetyl-CoARegulation of TCA CycleProtein/amino acidCatabolites feedInto the TCA CycleFats breakdown and feedinto the TCA CycleTCA Cycle provides intermediates for many biosynthetic processesThe Anaplerotic ReactionsThe "filling up" reactions PEP carboxylase - converts PEP to oxaloacetate Pyruvate carboxylase - converts pyruvate to oxaloacetate Malic enzyme converts pyruvate into malate Following the carbons through the TCA cycle